A Metabolic Bottleneck for Stem Cell Transformation

Sanjeethan C Baksh; Elaine Fuchs

doi:10.1016/j.cell.2020.08.038

A Metabolic Bottleneck for Stem Cell Transformation

Cell. 2020 Sep 17;182(6):1377-1378. doi: 10.1016/j.cell.2020.08.038.

Authors

Sanjeethan C Baksh¹, Elaine Fuchs²

Affiliations

¹ Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.
² Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA. Electronic address: fuchs@rockefeller.edu.

Abstract

Although oncogenic mutations predispose tissue stem cells to tumor initiation, the rate-limiting processes for stem cell immortalization remain unknown. In this issue of Cell, Bonnay et al. identify enhanced electron transport chain activity as a critical determinant of this process, establishing metabolic reprogramming as limiting for tumor initiation.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Carcinogenesis
Cell Transformation, Neoplastic*
Humans
Neural Stem Cells*
Oxidative Stress

Abstract

Publication types

MeSH terms

Grants and funding