The authors describe a very rare case of feto-placental anasarca of non-immunological cause (AFPNI) which was secondary to a fetal neuroblastoma. The diagnosis was suspected before birth thanks to ultrasound. After birth a further ultrasound study as well as an anatomo-pathological study were carried out. This, then, is a case history of a stage "IV-S" neuroblastoma, which is also called Pepper's syndrome. The pathological condition is described.