Tissue-resident memory-like T cells in tumor immunity: Clinical implications

Abstract

Tissue-resident memory (T_RM) T cells are distinct population of non-circulating lymphocytes that play an important role in mediating regional immunity. T_RM- like cells have now been identified as a component of tumor-infiltrating lymphocytes in several human tumors and correlate with outcome and response to immunotherapy. T_RM cells have also been shown to mediate anti-tumor immunity in murine models. Biology of T_RM cells has several implications for clinical cancer immunotherapy. Here we discuss newer insights into the biology of T_RM T cells and discuss their implications for understanding the heterogeneity of immune microenvironment in tumors as well as improving the efficacy of cancer vaccines, immune-checkpoint blockade and adoptive cellular therapies in the clinic.

Keywords: Tissue resident memory; Tumor immunity; Tumor infiltrating lymphocytes.