Focal small bowel thrombotic microvascular injury in COVID-19 mediated by the lectin complement pathway masquerading as lupus enteritis

Rheumatology (Oxford). 2021 Feb 1;60(2):e61-e63. doi: 10.1093/rheumatology/keaa627.

Authors

Benjamin Plotz¹, Rochelle Castillo¹, Jonathan Melamed², Cynthia Magro³, Pamela Rosenthal¹, H Michael Belmont¹

Affiliations

¹ Department of Rheumatology, New York, NY, USA.
² Department of Pathology, New York University Langone Health, New York, NY, USA.
³ Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adult
COVID-19 / complications
COVID-19 / diagnostic imaging
COVID-19 / immunology
COVID-19 / pathology*
Complement Pathway, Mannose-Binding Lectin / immunology
Complement System Proteins / immunology
Diagnosis, Differential
Duodenal Diseases / diagnostic imaging
Duodenal Diseases / etiology
Duodenal Diseases / immunology
Duodenal Diseases / pathology*
Edema / diagnostic imaging
Edema / etiology
Endoscopy, Digestive System
Enteritis / diagnosis*
Female
Fibrin Fibrinogen Degradation Products / metabolism
Humans
Immunohistochemistry
Intestinal Mucosa / blood supply
Intestinal Mucosa / pathology*
Ischemia / pathology
Lupus Erythematosus, Systemic / complications
Lupus Erythematosus, Systemic / diagnosis*
Lupus Erythematosus, Systemic / immunology
Microvessels / pathology*
Necrosis
SARS-CoV-2
Thrombotic Microangiopathies / diagnosis
Thrombotic Microangiopathies / etiology
Thrombotic Microangiopathies / immunology
Thrombotic Microangiopathies / pathology*
Tomography, X-Ray Computed

Substances

Fibrin Fibrinogen Degradation Products
fibrin fragment D
Complement System Proteins