Cardiac Conduction Defects in Systemic Lupus Erythematosus

Shayan Butt; Simra Kiran; Nida Qadir; Divya Menghani; Hammad Tanzeem

doi:10.7759/cureus.10882

Cardiac Conduction Defects in Systemic Lupus Erythematosus

Cureus. 2020 Oct 10;12(10):e10882. doi: 10.7759/cureus.10882.

Authors

Shayan Butt¹, Simra Kiran², Nida Qadir³, Divya Menghani³, Hammad Tanzeem⁴

Affiliations

¹ Internal Medicine, Baptist Memorial Hospital, Oxford, USA.
² Pulmonology and Critical Care, University of Cincinnati Medical Center, Cincinnati, USA.
³ Infectious Diseases, University of Louisville, Louisville, USA.
⁴ Medicine, Dow Medical College/Civil Hospital, Karachi, PAK.

Abstract

Systemic autoimmune conditions may cause morbidity and mortality. Systemic lupus erythematosus (SLE) is a prominent example of such diseases. It can result in conduction abnormalities due to accelerated atherosclerosis, vasculitis, or autoantibodies-induced myocarditis. Cardiac conduction abnormalities may produce sinus tachycardia, sinus bradycardia, prolonged QT intervals, atrial fibrillation, or atrioventricular (AV) nodal blocks. Neonatal lupus is sometimes associated with anti-Ro/SSA and anti-La/SSB antibodies, but their role remains a matter of controversy in adults.

Keywords: anti-la/ssb; anti-ro/ssa; cardiac lupus.

Publication types

Review