Correlation between obesity and clinicopathological characteristics in patients with papillary thyroid cancer: a study of 1579 cases: a retrospective study

Huijuan Wang; Pingping Wang; Yu Wu; Xiukun Hou; Zechun Peng; Weiwei Yang; Lizhao Guan; Linfei Hu; Jingtai Zhi; Ming Gao; Xiangqian Zheng

doi:10.7717/peerj.9675

Correlation between obesity and clinicopathological characteristics in patients with papillary thyroid cancer: a study of 1579 cases: a retrospective study

PeerJ. 2020 Sep 8:8:e9675. doi: 10.7717/peerj.9675. eCollection 2020.

Authors

Huijuan Wang¹, Pingping Wang², Yu Wu³, Xiukun Hou¹, Zechun Peng⁴, Weiwei Yang⁵, Lizhao Guan⁶, Linfei Hu¹, Jingtai Zhi¹, Ming Gao¹, Xiangqian Zheng¹

Affiliations

¹ Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
² Department of Thyroid and Breast Surgery, Rizhao Central Hospital, Shandong, China.
³ Department of Head and Neck Surgery, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fujian, China.
⁴ Department of Urology Surgery, AreaII, The Second Affiliated Hospital of Hainan Medical University, Hainan, China.
⁵ Department of Otolaryngology-Head and Neck Surgery, Tianjin First Center Hospital, Tianjin, China.
⁶ Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

Abstract

Objective: To explore the relationship between body mass index (BMI) and clinicopathological characteristics in patients with papillary thyroid carcinoma (PTC).

Methods: The clinical data of 1,579 patients with PTC, admitted to our hospital from May 2016 to March 2017, were retrospectively analyzed. According to the different BMI of patients, it can be divided into underweight recombination (BMI < 18.5 kg/m), normal body recombination (18.5 ≤ BMI < 24.0 kg/m²), overweight recombination (24.0 ≤ BMI < 28.0 kg/m²) and obesity group (BMI ≥ 28.0 kg/m²). The clinicopathological characteristics of PTC in patients with different BMIs group were compared.

Results: In our study, the risk for extrathyroidal extension (ETE), advanced T stage (T III/IV), and advanced tumor-node-metastasis stage (TNM III/IV) in the overweight group were higher, with OR (odds ratio) = 1.99(1.41-2.81), OR = 2.01(1.43-2.84), OR = 2.94(1.42-6.07), respectively, relative to the normal weight group. The risk for ETE and T III/IV stage in the obese group were higher, with OR = 1.82(1.23-2.71) and OR = 1.82(1.23-2.70), respectively, relative to the normal weight group.

Conclusion: BMI is associated with the invasiveness of PTC. There is a higher risk for ETE and TNM III/IV stage among patients with PTC in the overweight group and for ETE among patients with PTC in the obese group.

Keywords: Correlation; Papillary thyroid cancer; Body mass index.

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (Grant Nos. 81872169, 81702629), the Tianjin key research and development program science and technology support key projects (Grant No. 17YFZCSY00690), and the Tianjin Municipal Science and technology project (Grant No. 19JCYBJC27400). There was no additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.