What Does the APP Family Do in the Brain?

Ottavio Arancio

doi:10.1016/j.neuron.2020.11.003

What Does the APP Family Do in the Brain?

Neuron. 2020 Nov 25;108(4):583-585. doi: 10.1016/j.neuron.2020.11.003.

Author

Ottavio Arancio¹

Affiliation

¹ Department of Pathology and Cell Biology, Columbia University, 630W 168(th) Street, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630W 168(th) Street, New York, NY 10032, USA; Department of Medicine, Columbia University, 630W 168(th) Street, New York, NY 10032, USA. Electronic address: oa1@columbia.edu.

Abstract

Amyloid-β precursor protein (APP) is overshadowed by its degradation product, the Alzheimer protein Aβ. Lee et al. now find a role for the APP family in neuronal excitability, synaptic plasticity, and memory in adulthood, despite the lack of requirement for neuronal survival.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adult
Alzheimer Disease*
Amyloid beta-Protein Precursor* / genetics
Amyloid beta-Protein Precursor* / metabolism
Brain / metabolism
Humans
Neuronal Plasticity
Neurons / metabolism

Substances

Amyloid beta-Protein Precursor

Abstract

Publication types

MeSH terms

Substances

Grants and funding