Abstract
Aim: To determine the role of single nucleotide polymorphisms (SNPs) in noncoding RNAs in childhood acute lymphoblastic leukemia (ALL) subtypes. Materials & methods: We screened all SNPs in 130 pre-miRNA genes to assess their role in the susceptibility of the most common subtypes of ALL: hyperdiploid and ETV6-RUNX1. Results: In two independent cohorts, we found a significant association between rs10406069 in miR-5196 and the risk of developing hyperdiploid ALL. This observation could be explained by the impact of the SNP on miR-5196 expression and in turn, in its target genes. Indeed, rs10406069 was associated with expression changes in SMC1A, a gene involved in sister chromatin cohesion. Conclusion: rs10406069 in miR-5196 may have a relevant role in hyperdiploid ALL risk.
Keywords:
ALL; SMC1A; SNPs; hyperdiploid; miR-5196; rs10406069.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism
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Child
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Child, Preschool
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Chromosomal Proteins, Non-Histone / genetics
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Chromosomal Proteins, Non-Histone / metabolism
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Core Binding Factor Alpha 2 Subunit
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Diploidy
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Female
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Gene Expression Regulation, Leukemic
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Genotyping Techniques
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Humans
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Infant
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Male
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MicroRNAs / genetics*
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Oncogene Proteins, Fusion
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Polymorphism, Single Nucleotide*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
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RNA, Messenger / chemistry
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RNA, Messenger / genetics
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Structural Maintenance of Chromosome Protein 1
Substances
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Cell Cycle Proteins
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Chromosomal Proteins, Non-Histone
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Core Binding Factor Alpha 2 Subunit
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MIRN5196 microRNA, human
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MicroRNAs
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Oncogene Proteins, Fusion
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RNA, Messenger
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TEL-AML1 fusion protein
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Structural Maintenance of Chromosome Protein 1