Circadian and Sleep Dysfunctions in Neurodegenerative Disorders-An Update

Karim Fifel; Aleksandar Videnovic

doi:10.3389/fnins.2020.627330

Circadian and Sleep Dysfunctions in Neurodegenerative Disorders-An Update

Front Neurosci. 2021 Jan 18:14:627330. doi: 10.3389/fnins.2020.627330. eCollection 2020.

Authors

Karim Fifel¹, Aleksandar Videnovic²

Affiliations

¹ International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
² Movement Disorders Unit and Division of Sleep Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Abstract

Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered and multifactorial. Recent evidence suggests that sleep and circadian disturbances may influence the neurodegenerative processes as well as be their consequence. In this perspective, we provide an update of the current understanding of sleep and circadian dysregulation in Alzheimer's, Parkinson's, and Huntington's diseases.

Keywords: Alzheimer; Huntington; Parkinson; circadian system; sleep.

Publication types

Review

Abstract

Publication types

Grants and funding