A salience misattribution model for addictive-like behaviors

Abstract

Adapting to the changing environment is a key component of optimal decision-making. Internal-models that accurately represent and selectively update from behaviorally relevant/salient stimuli may facilitate adaptive behaviors. Anterior cingulate cortex (ACC) and dopaminergic systems may produce these adaptive internal-models through selective updates from behaviorally relevant stimuli. Dysfunction of ACC and dopaminergic systems could therefore produce misaligned internal-models where updates are disproportionate to the salience of the cues. An aspect of addictive-like behaviors is reduced adaptation and, ACC and dopaminergic systems typically exhibit dysfunction in drug-dependents. We argue that ACC and dopaminergic dysfunction in dependents may produce misaligned internal-models such that drug-related stimuli are misattributed with a higher salience compared to non-drug related stimuli. Hence, drug-related rewarding stimuli generate over-weighted updates to the internal-model, while negative feedback and non-drug related rewarding stimuli generate down-weighted updates. This misaligned internal-model may therefore incorrectly reinforce maladaptive drug-related behaviors. We use the proposed framework to discuss ways behavior may be made more adaptive and how the framework may be supported or falsified experimentally.

Keywords: Adaptation; Addiction; Anterior cingulate cortex; Decision-making; Dopamine; Internal-model updating; Prediction-errors; Salience.