We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.
Keywords: Fiebig stage; HIV; acute HIV infection; genetic diversity.
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.