Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection

Open Forum Infect Dis. 2020 Sep 12;7(10):ofaa429. doi: 10.1093/ofid/ofaa429. eCollection 2020 Oct.

Abstract

We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.

Keywords: Fiebig stage; HIV; acute HIV infection; genetic diversity.