Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection

Hongshuo Song; Meera Bose; Suteeraporn Pinyakorn; Eric Sanders-Buell; Anne Marie O'Sullivan; Daniel Silas; Rapee Trichavaroj; Bessara Nuntapinit; Phuc T Pham; Siriwat Akapirat; Eugène Kroon; Mark de Souza; Robert Gramzinski; Nelson L Michael; Merlin L Robb; Sandhya Vasan; Sodsai Tovanabutra; Jintanat Ananworanich

doi:10.1093/ofid/ofaa429

Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection

Open Forum Infect Dis. 2020 Sep 12;7(10):ofaa429. doi: 10.1093/ofid/ofaa429. eCollection 2020 Oct.

Authors

Hongshuo Song^{1

2

3}, Meera Bose^{1

2}, Suteeraporn Pinyakorn^{1

2}, Eric Sanders-Buell^{1

2}, Anne Marie O'Sullivan^{1

2}, Daniel Silas^{1

2}, Rapee Trichavaroj⁴, Bessara Nuntapinit⁴, Phuc T Pham^{1

2}, Siriwat Akapirat⁴, Eugène Kroon⁵, Mark de Souza^{1

2

5}, Robert Gramzinski^{1

2}, Nelson L Michael¹, Merlin L Robb^{1

2}, Sandhya Vasan^{1

2}, Sodsai Tovanabutra^{1

2}, Jintanat Ananworanich^{1

2

5

6}

Affiliations

¹ US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
² Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.
³ Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
⁴ Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
⁵ SEARCH, Thai Red Cross Research Centre, Bangkok, Thailand.
⁶ Department of Global Health, Amsterdam University Medical Centers, University of Amsterdam, and Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands.

Abstract

We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.

Keywords: Fiebig stage; HIV; acute HIV infection; genetic diversity.