Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019

Rev Soc Bras Med Trop. 2021 Mar 22:54:e0728-2020. doi: 10.1590/0037-8682-0728-2020. eCollection 2021.

Abstract

Introduction: Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide.

Methods: MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced.

Results: Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V).

Conclusions: The proportion of mono-SM-resistant TB among new patients was higher.

MeSH terms

  • Antitubercular Agents / pharmacology
  • Bacterial Proteins / genetics
  • China
  • Humans
  • Microbial Sensitivity Tests
  • Mutation
  • Mycobacterium tuberculosis* / genetics
  • Pharmaceutical Preparations*
  • Tuberculosis, Multidrug-Resistant*

Substances

  • Antitubercular Agents
  • Bacterial Proteins
  • Pharmaceutical Preparations