Contemporary trials evaluating neoadjuvant therapy for resectable pancreatic cancer

J Surg Oncol. 2021 May;123(6):1423-1431. doi: 10.1002/jso.26393.

Abstract

While the use of neoadjuvant therapy is well-accepted in the treatment of borderline resectable and locally advanced pancreatic cancers, the benefit of neoadjuvant chemotherapy in patients with resectable disease has been a topic of debate. Recently, key trials evaluating neoadjuvant chemotherapy for resectable pancreatic cancer have reported results. This review describes key clinical trials evaluating the use of preoperative therapy in patients with technically resectable pancreatic cancer with a focus on their contribution to the available evidence.

Keywords: chemotherapy; neoadjuvant therapy; pancreatic cancer; resectable pancreatic cancer.

Publication types

  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Clinical Trials, Phase III as Topic
  • Humans
  • Neoadjuvant Therapy
  • Pancreatic Neoplasms / drug therapy
  • Pancreatic Neoplasms / radiotherapy
  • Pancreatic Neoplasms / surgery
  • Pancreatic Neoplasms / therapy*
  • Preoperative Care / methods
  • Randomized Controlled Trials as Topic