Abnormally banded region in a poorly differentiated sarcoma is not correlated with amplification of c-MYC or c-MOS protooncogenes

Cancer Genet Cytogenet. 1988 Aug;34(1):111-5. doi: 10.1016/0165-4608(88)90175-6.

Abstract

A poorly differentiated sarcoma in a 32-year-old female revealed a large, abnormally banded region in one chromosome #8 in all metaphases. The modal karyotype was 46,XX, -8, +mar. Southern blot hybridization was performed with probes for two protooncogenes located in chromosome 8q (c-MYC and c-MOS). No amplification or rearrangement was observed to account for the cytogenetic abnormality.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Animals
  • Chromosome Aberrations*
  • Chromosome Banding
  • Chromosomes, Human, Pair 8*
  • DNA, Neoplasm / genetics
  • Female
  • Gene Amplification*
  • Humans
  • Karyotyping
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Nucleic Acid Hybridization
  • Proto-Oncogenes*
  • Sarcoma / genetics*
  • Sarcoma / pathology
  • Transplantation, Heterologous

Substances

  • DNA, Neoplasm