Take Your PIC

Trends Biochem Sci. 2021 Sep;46(9):705-707. doi: 10.1016/j.tibs.2021.05.008. Epub 2021 Jun 5.

Abstract

Cryo-electron microscopy has enabled unprecedented progress in the quest to reveal the structure of the whole transcription preinitiation complex. Four recent studies pave the way for a complete description of how transcription is initiated at near-atomic level.

Keywords: RNA polymerase II; cryo-EM; mediator; preinitiation complex; transcription.

MeSH terms

  • Cryoelectron Microscopy
  • Mediator Complex* / genetics
  • RNA Polymerase II* / metabolism
  • Transcription, Genetic

Substances

  • Mediator Complex
  • RNA Polymerase II