Take Your PIC

Alexis Verger; Didier Monté; Vincent Villeret

doi:10.1016/j.tibs.2021.05.008

Take Your PIC

Trends Biochem Sci. 2021 Sep;46(9):705-707. doi: 10.1016/j.tibs.2021.05.008. Epub 2021 Jun 5.

Authors

Alexis Verger¹, Didier Monté², Vincent Villeret²

Affiliations

¹ CNRS ERL 9002 Integrative Structural Biology, Inserm U1167 - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, Univ. Lille, CHU Lille, Institut Pasteur de Lille, F-59000 Lille, France. Electronic address: Alexis.Verger@univ-lille.fr.
² CNRS ERL 9002 Integrative Structural Biology, Inserm U1167 - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, Univ. Lille, CHU Lille, Institut Pasteur de Lille, F-59000 Lille, France.

PMID: 34103236
DOI: 10.1016/j.tibs.2021.05.008

Abstract

Cryo-electron microscopy has enabled unprecedented progress in the quest to reveal the structure of the whole transcription preinitiation complex. Four recent studies pave the way for a complete description of how transcription is initiated at near-atomic level.

Keywords: RNA polymerase II; cryo-EM; mediator; preinitiation complex; transcription.

MeSH terms

Cryoelectron Microscopy
Mediator Complex* / genetics
RNA Polymerase II* / metabolism
Transcription, Genetic

Substances

Mediator Complex
RNA Polymerase II