Losing control to bad relatives

Blood. 2021 Jun 24;137(25):3462-3463. doi: 10.1182/blood.2021011364.

Abstract

In this issue of Blood, Martin Merinero et al identified the mechanism of excessive complement activation caused by recurrent mutations in factor H–related protein-1 (FHR-1) in a few patients with atypical hemolytic uremic syndrome (aHUS). These are rare mutations in a rare disease, but the results provide a better understanding of complement regulation.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Truth Disclosure*