Detection of immunoglobulin response to COVID-19 vaccination using a novel rapid fingerstick assay

Clin Immunol. 2022 Feb:235:108791. doi: 10.1016/j.clim.2021.108791. Epub 2021 Jun 29.

Abstract

Coronavirus Disease 2019 (COVID-19) emerged as a global pandemic resulting in significant mortality and morbidity. COVID-19 vaccines have been shown to be highly effective in preventing COVID-19 infections and significantly reducing disease severity and mortality. We report on a novel COVID-19 antibody assay using a unique platform to rapidly detect SARS-CoV-2 antibodies with a drop of fingerstick blood in a subject following COVID-19 vaccination. We show early detection of SARS-CoV-2 antibodies post vaccination and persistence of detectable antibodies for at least 6 months. Rapid point of care COVID-19 antibody tests might have a role in assessing the appearance and durability of immune response following COVID-19 vaccination.

Keywords: Antibody; COVID-19; Fingerstick; Immunity; SARS-CoV-2; Serology; Test; Vaccination.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Antibodies, Viral / blood
  • Antibodies, Viral / immunology*
  • BNT162 Vaccine / administration & dosage
  • BNT162 Vaccine / immunology*
  • Blood Specimen Collection / methods*
  • COVID-19 / epidemiology
  • COVID-19 / immunology*
  • COVID-19 / virology
  • COVID-19 Serological Testing / methods
  • Fingers
  • Humans
  • Immunoglobulins / blood
  • Immunoglobulins / immunology*
  • Male
  • Middle Aged
  • Pandemics / prevention & control
  • Reproducibility of Results
  • SARS-CoV-2 / immunology*
  • SARS-CoV-2 / physiology
  • Vaccination

Substances

  • Antibodies, Viral
  • Immunoglobulins
  • BNT162 Vaccine