Interleukin-1RA Mitigates SARS-CoV-2-Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice

Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2773-2785. doi: 10.1161/ATVBAHA.121.316925. Epub 2021 Sep 9.

Abstract

[Figure: see text].

Keywords: SARS-CoV-2; edema; ies; interleukin-1; pyroptosis; vascular system injur.

MeSH terms

  • Animals
  • Antigens, CD / metabolism
  • COVID-19 / complications
  • COVID-19 / physiopathology*
  • COVID-19 Drug Treatment*
  • Cadherins / metabolism
  • Capillary Permeability
  • Caspase 1 / metabolism
  • Disease Models, Animal
  • Down-Regulation / drug effects
  • Edema / physiopathology
  • Edema / prevention & control
  • Endothelium, Vascular / drug effects
  • Enzyme Activation
  • Fibrosis / prevention & control
  • Interleukin 1 Receptor Antagonist Protein / therapeutic use*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • NLR Family, Pyrin Domain-Containing 3 Protein / metabolism
  • Neutrophils / physiology
  • Pulmonary Circulation
  • Receptors, Interleukin-1 / antagonists & inhibitors
  • Receptors, Interleukin-1 / physiology*
  • SARS-CoV-2
  • Signal Transduction / drug effects

Substances

  • Antigens, CD
  • Cadherins
  • Interleukin 1 Receptor Antagonist Protein
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Nlrp3 protein, mouse
  • Receptors, Interleukin-1
  • cadherin 5
  • Casp1 protein, mouse
  • Caspase 1