SARS-CoV-2 Infection in an Adolescent With X-linked Agammaglobulinemia

Pediatr Infect Dis J. 2021 Dec 1;40(12):e472-e474. doi: 10.1097/INF.0000000000003360.

Abstract

We present a case of a 17-year-old boy with X-linked agammaglobulinemia who had mild disease when initially infected with SARS-CoV-2 but after recovering from acute infection developed fevers and a raised erythrocyte sedimentation rate that persisted for several weeks without any ongoing respiratory symptoms. Multiple nasopharyngeal swabs were found to be negative for SARS-CoV-2 during the febrile period, but typical changes of COVID-19 on high resolution CT chest scan led to the detection of SARS-CoV-2 on RT-PCR in a sample from a bronchoalveolar lavage. His fevers completely resolved after a 5-day course of remdesivir.

Publication types

  • Case Reports

MeSH terms

  • Adenosine Monophosphate / analogs & derivatives
  • Adenosine Monophosphate / therapeutic use
  • Adolescent
  • Agammaglobulinemia / complications*
  • Alanine / analogs & derivatives
  • Alanine / therapeutic use
  • Antibodies, Viral / blood
  • Antiviral Agents / therapeutic use
  • Biomarkers / blood
  • Bronchoalveolar Lavage Fluid / virology
  • COVID-19 / complications*
  • COVID-19 Drug Treatment
  • Fever
  • Genetic Diseases, X-Linked / complications*
  • Humans
  • Inflammation / blood
  • Inflammation / metabolism
  • Male
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / pathology
  • Pneumonia, Viral / virology*
  • SARS-CoV-2* / isolation & purification

Substances

  • Antibodies, Viral
  • Antiviral Agents
  • Biomarkers
  • remdesivir
  • Adenosine Monophosphate
  • Alanine

Supplementary concepts

  • Bruton type agammaglobulinemia