[Acute leukemia secondary to idiopathic myelofibrosis with homozygote pseudo-Pelger anomaly and complex chromosomal changes]

Minerva Med. 1986 May 31;77(22-23):1023-6.
[Article in Italian]

Abstract

The Authors present a case of acute myeloblastic leukemia secondary to a busulfan and splenic radiotherapy treated idiopathic myelofibrosis. The presence of D group complex chromosomal abnormalities could be responsible for the simultaneous massive Pelger anomaly of granulocytes.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Busulfan / adverse effects
  • Chromosome Aberrations*
  • Chromosomes, Human, 13-15*
  • Female
  • Homozygote
  • Humans
  • Karyotyping
  • Leukemia, Myeloid, Acute / chemically induced
  • Leukemia, Myeloid, Acute / etiology*
  • Leukemia, Myeloid, Acute / genetics
  • Pelger-Huet Anomaly / diagnosis*
  • Pelger-Huet Anomaly / genetics
  • Primary Myelofibrosis / complications*
  • Primary Myelofibrosis / drug therapy
  • Primary Myelofibrosis / radiotherapy
  • Spleen / radiation effects

Substances

  • Busulfan