Reply to 'Impulse control disorders are associated with lower ventral striatum dopamine D3 receptor availability in Parkinson's disease: A [11C]-PHNO PET study.'

Pedro Barbosa; Bimali Hapuarachchi; Atbin Djamshidian; Kate Strand; Andrew J Lees; Rohan de Silva; Janice L Holton; Thomas T Warner

doi:10.1016/j.parkreldis.2021.11.003

Reply to 'Impulse control disorders are associated with lower ventral striatum dopamine D3 receptor availability in Parkinson's disease: A [11C]-PHNO PET study.'

Parkinsonism Relat Disord. 2021 Dec:93:31-32. doi: 10.1016/j.parkreldis.2021.11.003. Epub 2021 Nov 10.

Authors

Pedro Barbosa¹, Bimali Hapuarachchi², Atbin Djamshidian³, Kate Strand⁴, Andrew J Lees⁵, Rohan de Silva², Janice L Holton⁴, Thomas T Warner⁵

Affiliations

¹ Reta Lila Weston Institute of Neurological Studies, Department of Clinical Movement Disorder and Neuroscience, UCL Queen Square Institute of Neurology, London, UK; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK. Electronic address: p.barbosa@ucl.ac.uk.
² Reta Lila Weston Institute of Neurological Studies, Department of Clinical Movement Disorder and Neuroscience, UCL Queen Square Institute of Neurology, London, UK.
³ Reta Lila Weston Institute of Neurological Studies, Department of Clinical Movement Disorder and Neuroscience, UCL Queen Square Institute of Neurology, London, UK; Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.
⁴ Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
⁵ Reta Lila Weston Institute of Neurological Studies, Department of Clinical Movement Disorder and Neuroscience, UCL Queen Square Institute of Neurology, London, UK; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.

PMID: 34775278
DOI: 10.1016/j.parkreldis.2021.11.003

Abstract

Pagano and collaborators have recently reported lower ventral striatum D3 receptor availability in Parkinson's disease using PET scan. Our group conducted the first postmortem study of individuals with PD who had ICD and related behaviours in life and reported lower alpha-synuclein pathology and D3R levels in the nucleus accumbens of such individuals. The findings by Pagano and co-authors of low D3R binding in PD patients at baseline, when taken together with our findings of lower Lewy pathology and D3R in the nucleus accumbens, favour the hypothesis that D3R levels are downregulated because of excessive synaptic dopamine.

Keywords: Dopamine D3 receptors; Impulse control disorders; Parkinson's disease; Ventral striatum.

Publication types

Letter
Comment

MeSH terms

Carbon Radioisotopes
Disruptive, Impulse Control, and Conduct Disorders*
Humans
Parkinson Disease* / diagnostic imaging
Positron-Emission Tomography
Receptors, Dopamine D3
Ventral Striatum* / diagnostic imaging

Substances

Carbon Radioisotopes
Carbon-11
Receptors, Dopamine D3

Grants and funding

MR/L023784/2/MRC_/Medical Research Council/United Kingdom