Stem cell responses to stretch and strain

Swarnabh Bhattacharya; Haguy Wolfenson; Ramesh Shivdasani; Ruby Shalom-Feuerstein

doi:10.1016/j.tcb.2021.10.007

Stem cell responses to stretch and strain

Trends Cell Biol. 2022 Jan;32(1):4-7. doi: 10.1016/j.tcb.2021.10.007. Epub 2021 Nov 17.

Authors

Swarnabh Bhattacharya¹, Haguy Wolfenson², Ramesh Shivdasani³, Ruby Shalom-Feuerstein⁴

Affiliations

¹ Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: swarnabh_bhattacharya@dfci.harvard.edu.
² Department of Genetics & Developmental Biology, The Rappaport Faculty of Medicine & Research Institute, Technion Integrated Cancer Center, Technion - Israel Institute of Technology, 31096 Haifa, Israel.
³ Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02139, USA.
⁴ Department of Genetics & Developmental Biology, The Rappaport Faculty of Medicine & Research Institute, Technion Integrated Cancer Center, Technion - Israel Institute of Technology, 31096 Haifa, Israel. Electronic address: shalomfe@technion.ac.il.

PMID: 34801376
DOI: 10.1016/j.tcb.2021.10.007

Abstract

Recent studies highlight how stem cells (SCs) perceive and respond to various biomechanical cues from the extracellular niche and neighboring cells. These combined inputs drive certain stem cell behaviors, including cell fate decisions, and may influence aging and disease.

Keywords: cell fate; mechanobiology; niche; stem cells.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Biomechanical Phenomena*
Cell Differentiation / physiology
Humans
Stem Cells* / cytology

Abstract

Publication types

MeSH terms

Grants and funding