Objective: To compare the therapeutic results and the occurrence of adverse reactions of medicine between the combined therapy of warm acupuncture at back-shu points of five zang organs and the western medicine and the simple wes-tern medication, and observe the therapeutic effect and attenuating effect of this combined therapy in treatment on depression of yang deficiency pattern.
Methods: A total of 80 patients with depression of yang deficiency pattern were randomly divided into an observation group and a control group （39 cases/group）. In the control group, escitalopram oxalate tablets were administered orally every day. In the observation group, on the base of the medication as the control group, warm acupuncture therapy was exerted at back-shu points of five zang organs, for 30 min each time, 5 times a week. The duration of treatment was 6 weeks in two groups. Before and after treatment, the scores of Hamilton depression scale (HAMD) and the antidepressant side effect scale (SERS) were evaluated and electroencephalogram (EEG) was detected; and the curative effect was assessed according to HAMD reduction rate in patients of the two groups.
Results: After treatment, the HAMD and SERS scores were lower than those before treatment in both groups. Compared with the control group, the HAMD and SERS scores were lower (P<0.05, P<0.01), and the EEG result was improved (P<0.01) in the observation group. The clinical total effective rate of the observation group was 97.43% (38/39), higher than 92.30% (36/39) of the control group (P<0.05).
Conclusion: The combined therapy of warm acupuncture at back-shu points of five zang organs and western medicine effectively relieves depression of yang deficiency pattern in the patients and its overall therapeutic effect is better than simple western medication, besides, the combined therapy alleviates the adverse reactions induced by simple western medication.
目的：比较五脏背俞穴温针灸结合西药治疗与单纯西药治疗阳虚型郁证的疗效差异及减毒效应。方法：将80例阳虚型郁证患者随机分为对照组和观察组，每组39例。对照组予每天口服草酸艾司西酞普兰；观察组在对照组的基础上行五脏背俞穴温针灸，每天治疗30 min，每周治疗5次。两组均治疗6周。分别于治疗前后评定两组患者汉密尔顿抑郁量表(HAMD)、抗抑郁药副反应量表(SERS)评分，进行脑电图检测记录异常脑电图患者的例数，并根据HAMD评分减分率来评定两组的疗效。结果：与本组治疗前比较，两组治疗后HAMD、SERS评分显著降低(P<0.01)；治疗后与对照组比较，观察组HAMD、SERS评分降低(P<0.05，P<0.01)，脑电图检测结果优于对照组(P<0.05)。观察组临床总有效率为97.43%(38/39)，高于对照组的92.30%(36/39，P>0.05)。结论：五脏背俞穴温针灸结合西药治疗能有效改善阳虚型郁证患者的抑郁程度，总体疗效优于单纯西药治疗，并可减少单纯西药治疗所带来的药物不良反应。.
Keywords: Attenuating effect; Back-shu points of five zang organs; Depression; Escitalopram oxalate; Warming acupuncture; Yang deficiency pattern.