An automated radiosynthesis of [18F]DPA-714 on a commercially available radiosynthesizer, Elixys Flex/Chem

Katelyenn S McCauley; Justin H Wilde; Sophia M Bufalino; Kiel D Neumann

doi:10.1016/j.apradiso.2021.110032

An automated radiosynthesis of [¹⁸F]DPA-714 on a commercially available radiosynthesizer, Elixys Flex/Chem

Appl Radiat Isot. 2022 Feb:180:110032. doi: 10.1016/j.apradiso.2021.110032. Epub 2021 Nov 18.

Authors

Katelyenn S McCauley¹, Justin H Wilde¹, Sophia M Bufalino², Kiel D Neumann³

Affiliations

¹ Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA.
² Department of Chemistry, University of Virginia, Charlottesville, VA, USA.
³ Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA; Emily Couric Clinical Cancer Center, University of Virginia, Charlottesville, VA, USA. Electronic address: kdn2e@virginia.edu.

Abstract

[¹⁸F]DPA-714 is a radiotracer specific to the translocator protein (TSPO) and is useful for in vivo Positron Emission Tomography imaging studies. In this report, we have developed an automated radiosynthesis of [¹⁸F]DPA-714 on a commercially-available radiosynthesis platform, which comports with USP <823> guidelines. The wide availability of the radiosynthesis module and ease of dissemination of the production sequence will facilitate preclinical and clinical research of TSPO-related pathology.

Keywords: Automation; F-18; Fluorine-18; Positron emission tomography; Radiochemistry; Radiosynthesis.

Publication types

Review

Grants and funding

R01 EB028338/EB/NIBIB NIH HHS/United States