Ankyrin-2 genetic variants: A case of Ankyrin-B syndrome

Ann Noninvasive Electrocardiol. 2022 Jul;27(4):e12933. doi: 10.1111/anec.12933. Epub 2022 Feb 28.

Abstract

Inherited cardiac arrhythmias (ICA) have become one of the leading causes of sudden cardiac death in people under 40 years old. Variants in the ankyrin-B or ankyrin-2 genes will result in several cardiac arrhythmias ranging from sinus node dysfunction to life-threatening arrhythmias. In this case study, we report a typical ankyrin-2 variant, in which ventricular tachyarrhythmias might be reproduced through exercise or stress tests.

Keywords: Ankyrin-B syndrome; ankyrin 2; genetic mutations; inherited cardiac arrhythmias.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Ankyrins* / genetics
  • Arrhythmias, Cardiac
  • Death, Sudden, Cardiac / etiology
  • Electrocardiography*
  • Humans

Substances

  • Ankyrins

Supplementary concepts

  • Cardiac Arrhythmia, Ankyrin-B-Related