Cross-species microRNA transmission modulates flavivirus growth in mosquitoes

Shwetha Shivaprasad; Peter Sarnow

doi:10.1016/j.pt.2022.02.007

Cross-species microRNA transmission modulates flavivirus growth in mosquitoes

Trends Parasitol. 2022 May;38(5):349-350. doi: 10.1016/j.pt.2022.02.007. Epub 2022 Mar 1.

Authors

Shwetha Shivaprasad¹, Peter Sarnow²

Affiliations

¹ Department of Microbiology & Immunology, Stanford University SOM, Stanford, CA 94305, USA.
² Department of Microbiology & Immunology, Stanford University SOM, Stanford, CA 94305, USA. Electronic address: psarnow@stanford.edu.

PMID: 35246384
DOI: 10.1016/j.pt.2022.02.007

Abstract

Mosquitoes can be infected with a variety of RNA viruses. Recently,Zhu et al. demonstrated that human microRNA hsa-miR-150-5p is acquired by mosquitoes during blood meals and protects the Dengue virus by downregulation of chymotrypsin AaCT-1 mRNA. This finding suggests the use of microRNA antagomirs as an antiviral approach in mosquitoes.

Keywords: RNAi; chymotrypsin; flavivirus; microRNA; mosquito; transmission.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Aedes* / genetics
Animals
Culicidae* / physiology
Flavivirus* / genetics
Humans
MicroRNAs* / genetics
Mosquito Vectors / genetics

Substances

MicroRNAs

Grants and funding

R01 AI069000/AI/NIAID NIH HHS/United States