Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion

Affiliations

• ¹ Department of Pathology, University of Utah, Salt Lake City, UT, USA.
• ² Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
• ³ Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
• ⁴ Department of Medicine and Transplant/Cell Therapy Program, University of Maryland School of Medicine and Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
• ⁵ Department of Pharmaceutics & Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA.
• ⁶ Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
• ⁷ Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• ⁸ Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
• ⁹ Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. tluetkens@som.umaryland.edu.
• ¹⁰ Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA. tluetkens@som.umaryland.edu.
• ¹¹ Department of Medicine and Transplant/Cell Therapy Program, University of Maryland School of Medicine and Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA. tluetkens@som.umaryland.edu.