Transcriptional preservation of serotonergic connectivity may shed light on neurodegeneration

Mariano Soiza-Reilly

doi:10.1016/j.tins.2022.05.004

Transcriptional preservation of serotonergic connectivity may shed light on neurodegeneration

Trends Neurosci. 2022 Aug;45(8):563-565. doi: 10.1016/j.tins.2022.05.004. Epub 2022 May 24.

Author

Mariano Soiza-Reilly¹

Affiliation

¹ Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina. Electronic address: msoizareilly@fbmc.fcen.uba.ar.

PMID: 35624030
DOI: 10.1016/j.tins.2022.05.004

Abstract

In a recent study, Kitt, Tabuchi, and colleagues unveiled a novel function of an early-stage transcriptional network to maintain the adult integrity of serotonergic connectivity. Reported axonal and synaptic morphological alterations in serotonin (5-HT) neurons after selective inactivation of Lmx1b/Pet1 transcriptional networks may help to understand aging and neurodegenerative processes.

Keywords: 5-HT; Lmx1b; Pet1; aging; axons; synapses.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Axons / physiology
Humans
Neurons / physiology
Serotonin*
Transcription Factors*

Substances

Transcription Factors
Serotonin