Efficient capture and stabilization of iodine via gas-solid reaction using cyclodextrin metal-organic frameworks

Jiacai Chen; Tao Guo; Xiaohong Ren; Ting Yang; Kaikai Zhang; Yuhua Guo; Xiaojin Chen; Shuangying Gui; Shujun Wang; Qianqian Li; Can Peng; Jiwen Zhang; Li Wu

doi:10.1016/j.carbpol.2022.119507

Efficient capture and stabilization of iodine via gas-solid reaction using cyclodextrin metal-organic frameworks

Carbohydr Polym. 2022 Sep 1:291:119507. doi: 10.1016/j.carbpol.2022.119507. Epub 2022 Apr 25.

Authors

Jiacai Chen¹, Tao Guo², Xiaohong Ren³, Ting Yang¹, Kaikai Zhang⁴, Yuhua Guo², Xiaojin Chen⁵, Shuangying Gui⁶, Shujun Wang⁷, Qianqian Li², Can Peng⁸, Jiwen Zhang⁹, Li Wu¹⁰

Affiliations

¹ School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210046, China; Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China.
² Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China.
³ Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
⁴ Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China; Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
⁵ Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China; Anhui University of Chinese Medicine, Hefei 230012, China.
⁶ Anhui University of Chinese Medicine, Hefei 230012, China; Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei 230012, China.
⁷ Shenyang Pharmaceutical University, Shenyang 110016, China.
⁸ Anhui University of Chinese Medicine, Hefei 230012, China; Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei 230012, China. Electronic address: pengcan@ahtcm.edu.cn.
⁹ School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210046, China; Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China; NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, National Institutes for Food and Drug Control, Beijing 100050, China. Electronic address: jwzhang@simm.ac.cn.
¹⁰ Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China; Anhui University of Chinese Medicine, Hefei 230012, China; Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei 230012, China. Electronic address: wuli@simm.ac.cn.

PMID: 35698323
DOI: 10.1016/j.carbpol.2022.119507

Abstract

For treatment of wound infection with stabilized iodine, potassium iodide cyclodextrin metal-organic frameworks (KI-CD-MOF) was prepared to carry iodine via gas-solid reaction. Apart from highly ordered porous frameworks, KI-CD-MOF contains uniformly distributed iodide ions which stabilize iodine (I₂). X-ray photoelectron spectroscopy and potentiometric titration were utilized to confirm the formation of I₃^- in the highly porous KI-CD-MOF as I₂@KI-CD-MOF. Molecular simulation and characterizations of the synchrotron radiation Fourier transform infrared spectroscopy, differential scanning calorimeter, powder X-ray diffraction and N₂ adsorption were conducted to illustrate the inclusion mechanism of iodine in I₂@KI-CD-MOF. The apparent solubility of iodine in water was 3.86 times enhanced. The stability and antibacterial activity tests demonstrated that the highly-dispersed iodide ions in KI-CD-MOF are crucial in improvement to the solubility, stability, and bacteriostatic effects of active iodide. Therefore, KI-CD-MOF has broad application prospects and advantages in efficiently capturing and stabilizing iodine.

Keywords: Bacteriostatic effect; Cyclodextrin metal-organic frameworks; Iodine; Solubility; Stabilization.

MeSH terms

Cyclodextrins* / chemistry
Iodides
Iodine*
Metal-Organic Frameworks* / chemistry
Solubility

Substances

Cyclodextrins
Iodides
Metal-Organic Frameworks
Iodine