Local recurrence of robot-assisted total mesorectal excision: a multicentre cohort study evaluating the initial cases

Int J Colorectal Dis. 2022 Jul;37(7):1635-1645. doi: 10.1007/s00384-022-04199-3. Epub 2022 Jun 16.

Abstract

Purpose: Evidence regarding local recurrence rates in the initial cases after implementation of robot-assisted total mesorectal excision is limited. This study aims to describe local recurrence rates in four large Dutch centres during their initial cases.

Methods: Four large Dutch centres started with the implementation of robot-assisted total mesorectal excision in respectively 2011, 2012, 2015, and 2016. Patients who underwent robot-assisted total mesorectal excision with curative intent in an elective setting for rectal carcinoma defined according to the sigmoid take-off were included. Overall survival, disease-free survival, systemic recurrence, and local recurrence were assessed at 3 years postoperatively. Subsequently, outcomes between the initial 10 cases, cases 11-40, and the subsequent cases per surgeon were compared using Cox regression analysis.

Results: In total, 531 patients were included. Median follow-up time was 32 months (IQR: 19-50]. During the initial 10 cases, overall survival was 89.5%, disease-free survival was 73.1%, and local recurrence was 4.9%. During cases 11-40, this was 87.7%, 74.1%, and 6.6% respectively. Multivariable Cox regression did not reveal differences in local recurrence between the different case groups.

Conclusion: Local recurrence rate during the initial phases of implantation of robot-assisted total mesorectal procedures is low. Implementation of the robot-assisted technique can safely be performed, without additional cases of local recurrence during the initial cases, if performed by surgeons experienced in laparoscopic rectal cancer surgery.

Keywords: Local recurrence; Rectal cancer; Robot-assisted surgery; Total mesorectal excision.

Publication types

  • Multicenter Study

MeSH terms

  • Cohort Studies
  • Disease-Free Survival
  • Humans
  • Laparoscopy*
  • Neoplasm Recurrence, Local / pathology
  • Rectal Neoplasms* / pathology
  • Robotics*
  • Treatment Outcome