Epidemiology of paediatric severe sepsis and septic shock in Turkey: Prevalence, results and treatments study

Gultac Evren; Utku Karaarslan; Dincer Yildizdas; Guntulu Şik; Ebru Azapağası; Capan Konca; Tanil Kendirli; Muhammed Udurgucu; Tolga Fikri Koroglu; Epidemiology of Pediatric Severe Sepsis and Septic Shock Study Group

doi:10.1111/apa.16484

Epidemiology of paediatric severe sepsis and septic shock in Turkey: Prevalence, results and treatments study

Acta Paediatr. 2022 Oct;111(10):1995-2003. doi: 10.1111/apa.16484. Epub 2022 Jul 19.

Authors

Gultac Evren¹, Utku Karaarslan², Dincer Yildizdas³, Guntulu Şik⁴, Ebru Azapağası⁵, Capan Konca⁶, Tanil Kendirli⁷, Muhammed Udurgucu⁸, Tolga Fikri Koroglu¹; Epidemiology of Pediatric Severe Sepsis and Septic Shock Study Group

Collaborators

Epidemiology of Pediatric Severe Sepsis and Septic Shock Study Group:
Agop Citak, Mutlu U Yazici, Merve Havan, Edin Botan, Nazik Yener, Resul Yilmaz, Alaaddin Yorulmaz, Ferhat Sari, Muhterem Duyu, Feyza G Incekoy, Nilufer Y Ozturk, Ilknur Tolunay, Bulent Karapinar, Pinar O Yazici, Serdar H Kihtir, Zeynep Kihtir, Ali E Arslankoylu, Mehmet Alakaya, Ayşe B Anil, Pinar Kulluoglu, Gazi Arslan, Oguz Dursun, Erdem Cebisli, Serhat Emeksiz, Oktay Perk, Nihal Akcay, Esra Sevketoglu, Faruk Ekinci, Arda M Kilinc, Alper Koker, Yasemin Coban, Murat Kangin, Mehmet N Talay, Arzu Oto, Nevin Kilic, Çağlar Odek, Hasan Agin, Ekin Soydan, Özlem T Koksoy, Mey T Petmezci, Umit Saritas, Gokhan Kalkan, Emine Akkuzu

Affiliations

¹ Pediatric ICU, Pediatrics, Dokuz Eylul University Hospital, Izmir, Turkey.
² Pediatric ICU, Pediatrics, University of Health Sciences, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
³ Pediatric ICU, Pediatrics, Çukurova University, Adana, Turkey.
⁴ Pediatric ICU, Pediatrics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
⁵ Pediatric ICU, Pediatrics, Sami Ulus Hospital, Ankara, Turkey.
⁶ Pediatric ICU, Pediatrics, Adiyaman University, Adiyaman, Turkey.
⁷ Pediatric ICU, Pediatrics, Ankara University, Ankara, Turkey.
⁸ Pediatric ICU, Pediatrics, 19 Mayıs University, Samsun, Turkey.

PMID: 35818128
DOI: 10.1111/apa.16484

Abstract

Aim: This study was aimed at characterising the prevalence, management and outcomes of paediatric severe sepsis and septic shock in tertiary paediatric intensive care units (PICUs) in Turkey.

Methods: A point prevalence study was conducted on 5 days over the course of 1 year in 29 PICUs in Turkey. Outcomes included severe sepsis and septic shock point prevalence, therapies used, duration of PICU stay and mortality at day 28.

Results: Of the 1757 children who were admitted to the PICU during the study period, 141 (8.0%) children met the consensus criteria for severe sepsis and 23 (1.3%) children met the criteria for septic shock. Paediatric severe sepsis and septic shock accounted for 8% and 1.3% of all PICU admissions, respectively. The median age of the patients was 2.6 years (interquartile range [IQR], 0.7-8.6 years). Enteral nutrition (79.3%) was preferred compared to parenteral nutrition (31.1%) for the first 3 days after PICU admission. A total of 39 patients died while in the PICU, for a 23.8% mortality rate, which did not vary by age.

Conclusion: The mortality rate was similar to that in other studies. Hematologic-immunologic comorbidity, parenteral nutrition and the use of vasoactive drugs were independently associated with mortality.

Keywords: intensive care units; mortality; paediatrics; septic shock; severe sepsis.