The matricellular protein thrombospondin-1 in lung inflammation and injury

Am J Physiol Cell Physiol. 2022 Sep 1;323(3):C857-C865. doi: 10.1152/ajpcell.00182.2022. Epub 2022 Aug 1.

Abstract

Matricellular proteins comprise a diverse group of molecular entities secreted into the extracellular space. They interact with the extracellular matrix (ECM), integrins, and other cell-surface receptors, and can alter matrix strength, cell attachment to the matrix, and cell-cell adhesion. A founding member of this group is thrombospondin-1 (TSP-1), a high molecular-mass homotrimeric glycoprotein. Given the importance of the matrix and ECM remodeling in the lung following injury, TSP-1 has been implicated in a number of lung pathologies. This review examines the role of TSP-1 as a damage controller in the context of lung inflammation, injury resolution, and repair in noninfectious and infectious models. This review also discusses the potential role of TSP-1 in human diseases as it relates to lung inflammation and injury.

Keywords: lung inflammation; lung injury; matricellular protein; thrombospondin-1.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Cell Adhesion
  • Extracellular Matrix / metabolism
  • Extracellular Matrix Proteins / metabolism
  • Humans
  • Pneumonia* / metabolism
  • Thrombospondin 1* / metabolism
  • Thrombospondins / metabolism

Substances

  • Extracellular Matrix Proteins
  • Thrombospondin 1
  • Thrombospondins