Germline Testing for the Evaluation of Hereditary Cancer Predisposition

Abstract

Germline testing for hereditary cancer predisposition has become increasingly important in the management of patients with cancer. Recent studies have demonstrated that hereditary cancer predisposition is more common than previously recognized and germline pathogenic variants may be actionable for patient treatment strategies. This article reviews the significance of hereditary cancer predisposition assessment and highlights the current practices in germline genetic testing approaches.

Keywords: Cancer; Genetic testing; Germline testing; Hereditary cancer predisposition.