Experience of double plasma purification in 603 patients from a single center in Shanghai, China

Abstract

Introduction: To summarize the clinical experiences with double plasma purification (DPP).

Method: Using Plasauto iQ automatic blood purification system, model KM-9000 for DPP.

Results: A total of 603 patients with different entity undergoing 811 purification procedures were included in this study. The most common purification modes were dual filtration plasma plasmapheresis (DFPP). Hyperlipidemia was the lead entity, 423 patients with hyperlipidemia performed DFPP, and two cases of severe acute pancreatitis caused by extremely high triglyceride levels completely recovered after two consecutive DFPP treatments. DFPP combined with immunosuppressants tended to decrease independent HD and reduced HD frequency in 53 patients with antineutrophil cytoplasmic antibody-associated vasculitis. Two patients developed hypotensive or hypoglycemia episodes, respectively, during purification procedures.

Conclusion: DPP is rapid for the treatment of patients with severe hyperlipidemia and acute pancreatitis caused by severely high triglyceride levels. For those who are intolerant to statins，DPP provides another treatment choice. DPP process is safe.

Keywords: ANCA-associated vasculitis; acute pancreatitis; double-filtration plasma plasmapheresis; hyperlipidemia; plasma purification.