Multisystem inflammatory syndrome in neonates associated with SARS-CoV-2 infection, a different entity?

J Neonatal Perinatal Med. 2023;16(1):169-177. doi: 10.3233/NPM-220990.

Abstract

Multisystemic inflammatory syndrome in children (MIS-C) is a novel disease that is associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). MIS-C usually affects children older than 5 years of age and adolescents, with a median of 8-years and an interquartile range of 3 to 11 years. A multisystemic inflammatory disease has been described in neonates and named MIS-N (multisystemic inflammatory syndrome in Neonates). We report three cases of Mexican newborns with MIS-N presenting with multiorgan compromise and a positive anti-SARS-CoV-2 IgG who developed Kawasaki disease (KD)-like cardiac features and discuss the current dilemma regarding diagnosis and treatment in these patients.

Keywords: COVID-19 neonate; SARS-CoV2; multisystem inflammatory syndrome in children.

MeSH terms

  • Adolescent
  • COVID-19* / complications
  • Child
  • Child, Preschool
  • Humans
  • Infant, Newborn
  • Mucocutaneous Lymph Node Syndrome* / complications
  • Mucocutaneous Lymph Node Syndrome* / diagnosis
  • RNA, Viral
  • SARS-CoV-2

Substances

  • RNA, Viral

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related
  • Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects