Dual GIPR and GLP-1R agonist tirzepatide inhibits aeroallergen-induced allergic airway inflammation in mouse model of obese asthma

Clin Exp Allergy. 2023 Feb;53(2):216-221. doi: 10.1111/cea.14252. Epub 2022 Nov 15.

Shinji Toki¹, Jian Zhang¹, Richard L Printz², Dawn C Newcomb^{1

3}, Katherine N Cahill², Kevin D Niswender^{3

4

5}, R Stokes Peebles Jr^{1

2

5}

¹ Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
² Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
³ Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
⁴ Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
⁵ Tennessee Valley Healthcare System, United States Department of Veterans Affairs, Nashville, Tennessee, USA.

No abstract available

Keywords: GIP; GLP-1; Th2; incretin mimetic drugs; obese asthma; tirzepatide.

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