Squamous Cell Carcinoma: An Update in Staging, Management, and Postoperative Surveillance Strategies

Anthony K Guzman; Chrysalyne D Schmults; Emily S Ruiz

doi:10.1016/j.det.2022.07.004

Squamous Cell Carcinoma: An Update in Staging, Management, and Postoperative Surveillance Strategies

Dermatol Clin. 2023 Jan;41(1):1-11. doi: 10.1016/j.det.2022.07.004. Epub 2022 Oct 28.

Authors

Anthony K Guzman¹, Chrysalyne D Schmults², Emily S Ruiz²

Affiliations

¹ Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: aguzman7@bwh.harvard.edu.
² Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

PMID: 36410970
DOI: 10.1016/j.det.2022.07.004

Abstract

The rising incidence of cutaneous squamous cell carcinoma (cSCC) represents a public health crisis. Although most cases of cSCC are cured with surgical excision alone, high-risk disease requires a coordinated strategy involving accurate staging, possible multimodal therapy, and clinical and radiologic surveillance. In the following review, we present an evidence-based update on the current paradigm of diagnosis and management of cSCC and discuss the most relevant areas of active research related to prognostic staging as well as the appropriate use of radiologic imaging and adjuvant therapy.

Keywords: Mohs micrographic surgery; Nonmelanoma skin cancer; SCC; Squamous cell carcinoma.

Publication types

Review

MeSH terms

Carcinoma, Squamous Cell* / diagnostic imaging
Carcinoma, Squamous Cell* / surgery
Humans
Neoplasm Staging
Prognosis
Skin Neoplasms* / diagnostic imaging
Skin Neoplasms* / surgery