Nickel-catalyzed alkylation of ketones and nitriles with primary alcohols

Org Biomol Chem. 2022 Dec 14;20(48):9753-9762. doi: 10.1039/d2ob01787c.

Abstract

Nickel(II)-salen or nickel(II)-salphen catalyzed α-alkylation of ketones and nitriles with primary alcohols is reported. Various α-alkylated ketones and nitriles were obtained in high yields through a borrowing hydrogen strategy by using 1-3 mol% of nickel catalyst and a catalytic amount of NaOH (5-10 mol%) under aerobic conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols
  • Alkylation
  • Catalysis
  • Ketones*
  • Nickel*
  • Nitriles

Substances

  • Ketones
  • Nickel
  • Alcohols
  • Nitriles