Size matters in non-canonical inflammasome activation and cell-mediated immunity

Adam M Weiss; Aaron P Esser-Kahn

doi:10.1016/j.xcrm.2022.100904

Size matters in non-canonical inflammasome activation and cell-mediated immunity

Cell Rep Med. 2023 Jan 17;4(1):100904. doi: 10.1016/j.xcrm.2022.100904.

Authors

Adam M Weiss¹, Aaron P Esser-Kahn²

Affiliations

¹ Pritzker School of Molecular Engineering, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637, USA.
² Pritzker School of Molecular Engineering, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637, USA. Electronic address: aesserkahn@uchicago.edu.

Abstract

Particulate adjuvants are key components of many approved vaccines, but their mechanism of adjuvanticity is debated. Muñoz-Wolf et al.¹ find that 50-nm particles maximize cell-mediated immune responses by activating the caspase-11 inflammasome, providing mechanistic insight to particulate adjuvant technologies.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adjuvants, Immunologic
Carrier Proteins
Immunity, Cellular
Inflammasomes* / metabolism
NLR Family, Pyrin Domain-Containing 3 Protein*

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein
Carrier Proteins
Adjuvants, Immunologic

Grants and funding

75N93019C00041/AI/NIAID NIH HHS/United States