Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates

Sci Rep. 2023 Mar 14;13(1):4219. doi: 10.1038/s41598-023-29428-9.

Emil Uffelmann¹, Danielle Posthuma^{2

3}, Wouter J Peyrot^{2

4}

¹ Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands. e.uffelmann@vu.nl.
² Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands.
³ Department of Child and Adolescent Psychiatry and Pediatric Psychology, Section Complex Trait Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam University Medical Center, Amsterdam, The Netherlands.
⁴ Department of Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands.

No abstract available

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