Single-tailed heterocyclic carboxamide lipids for macrophage immune-modulation

Biomater Sci. 2023 Apr 11;11(8):2693-2698. doi: 10.1039/d2bm01804g.

Abstract

The discovery of new immune-modulating biomaterials is of significant value to immuno-engineering and therapy development. Here, we discovered that single-tailed heterocyclic carboxamide lipids preferentially modulated macrophages - but not dendritic cells - by interfering with sphingosine-1-phosphate-related pathways, consequently increasing interferon alpha expression. We further performed extensive downstream correlation analysis and determined key factors in physicochemical properties likely to modulate pro-inflammatory and anti-inflammatory immune responses. These properties will be useful for the rational design of the next generation of cell type-specific immune-modulating lipids.

MeSH terms

  • Biocompatible Materials* / metabolism
  • Immunity
  • Lipids
  • Macrophages* / metabolism

Substances

  • Biocompatible Materials
  • Lipids