Gain-of-function variants in the KDF1 gene cause hidradenitis suppurativa associated with ectodermal dysplasia by stabilizing IκB kinase α
Br J Dermatol
.
2023 Jul 7;189(1):131-132.
doi: 10.1093/bjd/ljad075.
Authors
Alban Ziegler
1
,
Frédéric Ebstein
2
3
,
Hanan Shamseldin
4
,
Clément Prouteau
1
,
Elke Krüger
2
,
Yousef M Binamer
5
,
Dominique Bonneau
1
,
Fowzan S Alkuraya
4
,
Ludovic Martin
6
Affiliations
1
Department of Genetics.
2
Institut für Medizinische Biochemie und Molekularbiologie (IMBM), Universitätsmedizin Greifswald, Ferdinand-Sauerbruch-Straße, 17475 Greifswald, Germany.
3
Nantes Université, Inserm UMR 1087/CNRS UMR 6291, l'Institut du Thorax, 44000 Nantes, France.
4
Department of Translational Genomics, Center for Genomic Medicine.
5
Department of Dermatology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
6
Department of Dermatology, University Hospital Angers, 4 rue Larrey, Angers Cedex 9 49333, France.
PMID:
37144643
DOI:
10.1093/bjd/ljad075
No abstract available
Publication types
Case Reports
MeSH terms
Adolescent
Ectodermal Dysplasia* / genetics
Gain of Function Mutation
Hidradenitis Suppurativa* / complications
Hidradenitis Suppurativa* / genetics
Humans
I-kappa B Kinase / genetics
Male
Substances
I-kappa B Kinase
Grants and funding
King Salman Center for Disability Research