Functional screens refine height GWAS loci

Cheryl L Ackert-Bicknell

doi:10.1016/j.xgen.2023.100325

Functional screens refine height GWAS loci

Cell Genom. 2023 May 10;3(5):100325. doi: 10.1016/j.xgen.2023.100325.

Author

Cheryl L Ackert-Bicknell^{1

2}

Affiliations

¹ Colorado Program for Musculoskeletal Research, Department of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
² Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Abstract

Genome-wide association studies (GWASs) have demonstrated the complexity of human height. Baronas et al.¹ used a high-throughput CRISPR screen to identify genes that participate in growth plate chondrocyte maturation as a functional follow-up and validation screen to refine loci and establish causality after GWASs.

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