Measuring ART Adherence Among Young Adults with Perinatally Acquired HIV: Comparison Between Self-report, Telephone-Based Pill Count, and Objective Pharmacologic Measures

R N Robbins; L Kluisza; N Nguyen; C Dolezal; C S Leu; A Wiznia; E J Abrams; P L Anderson; J R Castillo-Mancilla; C A Mellins

doi:10.1007/s10461-023-04107-y

Measuring ART Adherence Among Young Adults with Perinatally Acquired HIV: Comparison Between Self-report, Telephone-Based Pill Count, and Objective Pharmacologic Measures

AIDS Behav. 2023 Dec;27(12):3927-3931. doi: 10.1007/s10461-023-04107-y. Epub 2023 Jun 16.

Authors

R N Robbins¹, L Kluisza², N Nguyen³, C Dolezal², C S Leu², A Wiznia⁴, E J Abrams⁵, P L Anderson⁶, J R Castillo-Mancilla⁶, C A Mellins²

Affiliations

¹ HIV Center for Clinical and Behavioral Studies, Columbia University and New York State Psychiatric Institute, New York, USA. rnr2110@cumc.columbia.edu.
² HIV Center for Clinical and Behavioral Studies, Columbia University and New York State Psychiatric Institute, New York, USA.
³ Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, USA.
⁴ Department of Pediatrics, Albert Einstein College of Medicine and Jacobi Medical Center, Bronx, NY, USA.
⁵ Mailman School of Public Health, ICAP at Columbia University, New York, USA.
⁶ University of Colorado Anschutz Medical Campus School of Medicine, Aurora, USA.

Abstract

Tenofovir diphosphate (TVF-DP) can be quantified in red blood cells (RBCs) and dried blood spots (DBS) and can objectively measure ART adherence and predict viral suppression. Data on the association of TFV-DP with viral load are very limited in adolescents and young adults (AYA) living with perinatally-acquired HIV (PHIV), as are data comparing TFV-DP to other measures of ART adherence, such as self-report and unannounced telephone pill count. Viral load and ART adherence (self-report, TFV-DP and unannounced telephone pill count) were assessed and compared among 61 AYAPHIV recruited from an ongoing longitudinal study (CASAH) in New York City.

Keywords: ART; Adherence; Measures; Perinatal HIV infection; Self-report; Tenofovir diphosphate; Unannounced telephone pill count.

MeSH terms

Adolescent
Anti-HIV Agents* / therapeutic use
HIV Infections* / drug therapy
Humans
Longitudinal Studies
Medication Adherence
Self Report
Telephone
Young Adult

Substances

Anti-HIV Agents

Abstract

MeSH terms

Substances

Grants and funding