Au(I)-Catalyzed Regioselective Hydrofluorination of Propargylamines Using Aqueous HF

J Org Chem. 2023 Aug 18;88(16):12074-12078. doi: 10.1021/acs.joc.3c00594. Epub 2023 Jul 26.

Abstract

Gold-catalyzed regioselective hydrofluorination of alkynes using aqueous HF has been achieved by employing an amide directing group. For both aryl- and alkyl-substituted propargylamines, the fluorination occurred at the site distal to the amino group.