Unprovoked Venous Thromboembolism: The Search for the Cause

Hunter Mwansa; Mohamed Zghouzi; Geoffrey D Barnes

doi:10.1016/j.mcna.2023.05.006

Unprovoked Venous Thromboembolism: The Search for the Cause

Med Clin North Am. 2023 Sep;107(5):861-882. doi: 10.1016/j.mcna.2023.05.006. Epub 2023 Jun 26.

Authors

Hunter Mwansa¹, Mohamed Zghouzi¹, Geoffrey D Barnes²

Affiliations

¹ Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, USA.
² Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, USA. Electronic address: gbarnes@med.umich.edu.

PMID: 37541713
DOI: 10.1016/j.mcna.2023.05.006

Abstract

Venous thromboembolism (VTE) is a common vascular disorder encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE). There is no data on global estimates of VTE prevalence and incidence. Most patients with unprovoked VTE require secondary thromboprophylaxis upon the completion of the primary treatment phase if they have no high bleeding risk. Risk prediction models can help identify patients at low VTE recurrence risk who may discontinue anticoagulation upon the completion of the primary treatment phase.

Keywords: Anticoagulation; Evaluation; Recurrence risk assessment; Thrombophilia; Unprovoked venous thromboembolism.

Publication types

Review

MeSH terms

Anticoagulants / therapeutic use
Hemorrhage / chemically induced
Humans
Pulmonary Embolism* / drug therapy
Pulmonary Embolism* / epidemiology
Recurrence
Risk Factors
Venous Thromboembolism* / drug therapy
Venous Thromboembolism* / epidemiology
Venous Thromboembolism* / prevention & control
Venous Thrombosis* / drug therapy
Venous Thrombosis* / epidemiology
Venous Thrombosis* / etiology

Substances

Anticoagulants