cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

Nature. 1986 Apr;320(6064):695-9. doi: 10.1038/320695a0.

Abstract

The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Cell Line
  • Cell Transformation, Neoplastic
  • Chromosomes, Human, 6-12 and X
  • DNA
  • Genes
  • Humans
  • Hybrid Cells
  • Molecular Weight
  • Platelet-Derived Growth Factor / genetics*
  • RNA, Messenger

Substances

  • Platelet-Derived Growth Factor
  • RNA, Messenger
  • DNA

Associated data

  • GENBANK/X03795