Deconstructing the integrated oscillator model for pancreatic β-cells

Richard Bertram; Isabella Marinelli; Patrick A Fletcher; Leslie S Satin; Arthur S Sherman

doi:10.1016/j.mbs.2023.109085

Deconstructing the integrated oscillator model for pancreatic β-cells

Math Biosci. 2023 Nov:365:109085. doi: 10.1016/j.mbs.2023.109085. Epub 2023 Oct 4.

Authors

Richard Bertram¹, Isabella Marinelli², Patrick A Fletcher³, Leslie S Satin⁴, Arthur S Sherman³

Affiliations

¹ Department of Mathematics and Programs in Neuroscience and Molecular Biophysics, Florida State University, Tallahassee, FL, United States. Electronic address: bertram@math.fsu.edu.
² Centre for Systems Modeling and Quantitative Biomedicine, University of Birmingham, United Kingdom.
³ Laboratory of Biological Modeling, National Institutes of Health, Bethesda, MD, United States.
⁴ Department of Pharmacology and Brehm Center for Diabetes Research, University of Michigan Medical School, Ann Arbor, MI, United States.

Abstract

Electrical bursting oscillations in the β-cells of pancreatic islets have been a focus of investigation for more than fifty years. This has been aided by mathematical models, which are descendants of the pioneering Chay-Keizer model. This article describes the key biophysical and mathematical elements of this model, and then describes the path forward from there to the Integrated Oscillator Model (IOM). It is both a history and a deconstruction of the IOM that describes the various elements that have been added to the model over time, and the motivation for adding them. Finally, the article is a celebration of the 40th anniversary of the publication of the Chay-Keizer model.

Keywords: Beta-cells; Electrical bursting; Fast/slow analysis; Islets.

MeSH terms

Animals
Biological Clocks / physiology
Humans
Insulin-Secreting Cells* / physiology
Models, Biological*

Abstract

MeSH terms

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