Indirect cardiac output assessment in a swine pediatric acute respiratory distress syndrome model

Lorenzo A Miller; Rudolf K Braun; Regina J Golding; Michael Lasarev; Allison C Rodgers; Sarah El-Meanawy; Timothy A Hacker; Marlowe W Eldridge; Awni M Al-Subu

doi:10.1016/j.resp.2023.104199

Indirect cardiac output assessment in a swine pediatric acute respiratory distress syndrome model

Respir Physiol Neurobiol. 2024 Feb:320:104199. doi: 10.1016/j.resp.2023.104199. Epub 2023 Nov 23.

Authors

Lorenzo A Miller¹, Rudolf K Braun¹, Regina J Golding², Michael Lasarev³, Allison C Rodgers⁴, Sarah El-Meanawy⁴, Timothy A Hacker⁴, Marlowe W Eldridge¹, Awni M Al-Subu⁵

Affiliations

¹ Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
² Albert Einstein College of Medicine, The Bro nx, NY 10461, USA.
³ Department of Biostatistics & Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
⁴ Cardiovascular Physiology Core Facility, Department of Medicine, University of Wisconsin-Madison, Madison, WI 53792, USA.
⁵ Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA; UWHealth Kids American Family Children's Hospital, Madison, WI 53792, USA. Electronic address: al-subu@pediatrics.wisc.edu.

PMID: 38000708
DOI: 10.1016/j.resp.2023.104199

Abstract

Purpose: To investigate the correlation between volume of carbon dioxide elimination (V̇CO₂) and end-tidal carbon dioxide (PETCO₂) with cardiac output (CO) in a swine pediatric acute respiratory distress syndrome (ARDS) model.

Methods: Respiratory and hemodynamic variables were collected from twenty-six mechanically ventilated juvenile pigs under general anesthesia before and after inducing ARDS, using oleic acid infusion.

Results: Prior to ARDS induction, mean (SD) CO, V̇CO₂, PETCO₂, and dead space to tidal volume ratio (V_d/V_t) were 4.16 (1.10) L/min, 103.69 (18.06) ml/min, 40.72 (3.88) mmHg and 0.25 (0.09) respectively. Partial correlation coefficients between average CO, V̇CO₂, and PETCO₂ were 0.44 (95% confidence interval: 0.18-0.69) and 0.50 (0.18-0.74), respectively. After ARDS induction, mean CO, V̇CO₂, PETCO₂, and V_d/V_t were 3.33 (0.97) L/min, 113.71 (22.97) ml/min, 50.17 (9.73) mmHg and 0.40 (0.08). Partial correlations between CO and V̇CO₂ was 0.01 (-0.31 to 0.37) and between CO and PETCO₂ was 0.35 (-0.002 to 0.65).

Conclusion: ARDS may limit the utility of volumetric capnography to monitor CO.

Keywords: ARDS; Capnography; Cardiac output; Pediatrics; Swine; Volume of carbon dioxide elimination.

MeSH terms

Animals
Capnography
Carbon Dioxide*
Cardiac Output
Child
Humans
Respiration, Artificial
Respiratory Distress Syndrome*
Swine
Tidal Volume

Substances

Carbon Dioxide