Development of radiotracers for riboflavin transporter 3 imaging in diseases-A brief overview

J Labelled Comp Radiopharm. 2024 Feb;67(2):77-81. doi: 10.1002/jlcr.4076. Epub 2023 Dec 22.

Abstract

Riboflavin (RF, vitamin B2) plays a key role in metabolic oxidation-reduction reactions, especially in the mitochondrial reprogramming of energy metabolism. Riboflavin transporter 3 (RFVT3) is a vital section of the mitochondrial network and involved in riboflavin homeostasis and production of adenosine triphosphate (ATP). The abnormal expression of RFVT3 is closely associated with the occurrence and progression of multiple diseases. Therefore, it is vital to understand the riboflavin internalization pathway under pathological conditions by addressing the abnormal expression of RFVT3, which could be a highly valuable biomarker for the early diagnosis and effective therapy of various diseases.

Keywords: glioma; positron emission tomography; riboflavin transporter 3; single-photon emission computed tomography; stroke.

MeSH terms

  • Membrane Transport Proteins* / metabolism
  • Riboflavin* / metabolism

Substances

  • Membrane Transport Proteins
  • Riboflavin